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  • Title: Pneumocystis carinii pneumonia treated with eflornithine in AIDS patients resistant to conventional therapy.
    Author: Smith D, Davies S, Nelson M, Youle M, Gleeson J, Gazzard B.
    Journal: AIDS; 1990 Oct; 4(10):1019-21. PubMed ID: 2261116.
    Abstract:
    Eflornithine (DFMO) was used to treat 31 AIDS patients with confirmed Pneumocystis carinii pneumonia who had clinically failed treatment with pentamidine, sulphamethoxazole-trimethoprim or both agents as their first-line therapy. Twenty-one of 31 (68%) responded to second-line treatment with 400mg/kg per day of eflornithine. Five patients discontinued treatment because of bone marrow toxicity. Eflornithine appears to be a useful salvage therapy in patients failing first-line treatments.
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