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  • Title: Electrophilic trifluoromethylation by copper-catalyzed addition of CF3-transfer reagents to alkenes and alkynes.
    Author: Janson PG, Ghoneim I, Ilchenko NO, Szabó KJ.
    Journal: Org Lett; 2012 Jun 01; 14(11):2882-5. PubMed ID: 22612441.
    Abstract:
    Regio- and stereoselective Cu-catalyzed addition of the above hypervalent iodine reagent to alkynes and alkenes was achieved. In the presence of CuI, the reaction is suitable to perform trifluoromethyl-benzoyloxylation and trifluoromethyl-halogenation of alkenes and alkynes. Electron-donating substituents accelerate the process, and alkenes react faster than alkynes emphasizing the electrophilic character of the addition reaction.
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