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  • Title: Stereospecificity of hydrogen transfer in the saccharopine dehydrogenase reaction.
    Author: Fujioka M, Takata Y.
    Journal: Biochim Biophys Acta; 1979 Sep 12; 570(1):210-2. PubMed ID: 226150.
    Abstract:
    The stereospecificity of hydrogen transfer in the synthesis of saccharopine from alpha-ketoglutarate and L-lysine catalyzed by saccharopine dehydrogenase (N5-(1,3-dicarboxypropyl)-L-lysine: NAD oxidoreductase (L-lysine-forming), EC 1.5.1.7) was examined by using [4A-3H]- and [4B-3H]NADH. The enzyme showed the A-stereospecificity. The NMR analysis of the saccharopine prepared with [4"A-2H]NADH revealed that the label was incorporated into the C-2 of the glutaryl moiety.
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