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  • Title: Amylin release from perfused rat pancreas in response to glucose and arginine.
    Author: Inoue K, Hisatomi A, Umeda F, Nawata H.
    Journal: Diabetes Res Clin Pract; 1990 Oct; 10(2):189-92. PubMed ID: 2261856.
    Abstract:
    The effects of glucose and arginine on the release of amylin from the perfused rat pancreas were studied. Amylin, or islet amyloid polypeptide, is a 37-amino acid peptide isolated from pancreatic islet amyloid of patients with non-insulin-dependent diabetes mellitus (NIDDM). Glucose stimulated dose-dependently amylin release, showing a typical biphasic pattern. Additionally, 10 mM arginine in the presence of 5.5 mM glucose also stimulated amylin release. These findings suggest that amylin is a secretory protein and its release from the pancreas is regulated by glucose and other nutrients.
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