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  • Title: K-252a inhibits the response of tomato cells to fungal elicitors in vivo and their microsomal protein kinase in vitro.
    Author: Grosskopf DG, Felix G, Boller T.
    Journal: FEBS Lett; 1990 Nov 26; 275(1-2):177-80. PubMed ID: 2261987.
    Abstract:
    Two characteristic responses of plant cells to fungal elicitors, induction of phenylalanine ammonia-lyase activity and of ethylene biosynthesis, were studied in suspension-cultured tomato cells. Induction of both responses was completely blocked by 500 nM K-252a, a known inhibitor of mammalian protein kinases. About 100 nM K-252a caused half-maximal inhibition. In vitro, K-252a inhibited protein kinase activity in microsomal preparations from tomato cells. Inhibition was competitive with respect to ATP and had a Ki of about 15 nM. Thus, protein kinases sensitive to K-252a occur in plants and might be important for the plant's response to fungal elicitors.
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