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  • Title: Current state of domino transplantation in Japan in terms of surgical procedures and de novo amyloid neuropathy.
    Author: Asonuma K, Ohya Y, Isono K, Takeichi T, Yamamoto H, Lee KJ, Okumura K, Ando Y, Inomata Y.
    Journal: Amyloid; 2012 Jun; 19 Suppl 1():75-7. PubMed ID: 22620971.
    Abstract:
    The status of domino liver transplantation (DLT) in Japan was evaluated. DLT and familial amyloidotic polyneuropathy (FAP) recipients who underwent living donor liver transplantation (LDLT) at Kumamoto University were reviewed with attention to surgical procedures. Thirty-nine DLTs were performed in Japan until 2010, and survival rates at 1 and 3 years were 82% and 63.6%, respectively. Six of 21 DLT recipients who survived for more than 3 years developed amyloid depositions within organs, and de novo amyloid neuropathy was reported in three patients. DLT from FAP recipients in Kumamoto was safely performed with preservation of the retrohepatic inferior vena cava in FAP recipients. All 20 FAP recipients who were DLT donors are alive with the exception of one who died of the original FAP 9 years after LDLT. The outcomes of DLT and FAP recipients in Kumamoto were satisfactory.
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