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  • Title: Laxiflorolides A and B, epimeric bishomoditerpene lactones from Isodon eriocalyx.
    Author: Wang WG, Li XN, Du X, Wu HY, Liu X, Su J, Li Y, Pu JX, Sun HD.
    Journal: J Nat Prod; 2012 Jun 22; 75(6):1102-7. PubMed ID: 22624550.
    Abstract:
    Laxiflorolides A (1) and B (2), two unprecedented epimeric bishomoditerpene lactones with a unique C(22) framework, along with laxiflorins P-R (3-5), maoecrystal P (6), maoecrystal C (7), and eriocalyxin B (8), were isolated from the leaves of I. eriocalyx var. laxiflora. The structures of 1 and 2, including the absolute configurations, were determined by spectroscopic methods and single-crystal X-ray diffraction analysis. All of the compounds isolated were evaluated for their cytotoxicity against five tumor cell lines. Compounds 3, 6, and 8 showed remarkable cytotoxic activity against certain cell lines compared with the positive control.
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