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  • Title: CD4 costimulation is not required in a novel LPS-enhanced model of myasthenia gravis.
    Author: Allman W, Qi H, Saini SS, Li J, Tuzun E, Christadoss P.
    Journal: J Neuroimmunol; 2012 Aug 15; 249(1-2):1-7. PubMed ID: 22626443.
    Abstract:
    The potential of lipopolysaccharide (LPS) to induce antigen-specific B cell responses to acetylcholine receptor (AChR) in myasthenia gravis (MG) was evaluated in wild type (WT) and CD4-/- C57BL/6 mice. The WT mice immunized with AChR in LPS developed an MG-like disease (LPS-EAMG) similar to that induced by immunization with AChR in complete Freund's adjuvant (CFA-EAMG). CD4-/- mice were resistant to CFA-EAMG but susceptible to LPS-EAMG. LPS abrogated EAMG resistance in CD4-/- mice by increasing high-affinity anti-AChR IgG2b in sera and enhancing immune complex deposition in muscle.
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