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  • Title: A new ratiometric and colorimetric chemosensor for cyanide anion based on coumarin-hemicyanine hybrid.
    Author: Yang Z, Liu Z, Chen Y, Wang X, He W, Lu Y.
    Journal: Org Biomol Chem; 2012 Jul 14; 10(26):5073-6. PubMed ID: 22627395.
    Abstract:
    A hybrid coumarin-hemicyanine dye, Cou-BT, was developed as a new ratiometric and colorimetric sensor for cyanide with a sensing mechanism via nucleophilic addition of cyanide anion to the benzothiolium group. Cou-BT shows high sensitivity and selectivity for cyanide detection over other common anion species in aqueous acetonitrile solution. The calculated pseudo-first-order rate constant for cyanide anion addition was (2.13 ± 0.08) × 10(-2) s(-1) at 298 K, and the detection limit was estimated to be 0.64 μM. The DFT and TDDFT calculation results suggest that the ratiometric and colorimetric sensing behavior of Cou-BT upon its reaction with cyanide was due to the interrupted π-conjugation and blocked ICT progress.
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