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  • Title: Population-based pediatric reference intervals for general clinical chemistry analytes on the Abbott Architect ci8200 instrument.
    Author: Ridefelt P, Aldrimer M, Rödöö PO, Niklasson F, Jansson L, Gustafsson J, Hellberg D.
    Journal: Clin Chem Lab Med; 2012 Feb 29; 50(5):845-51. PubMed ID: 22628328.
    Abstract:
    BACKGROUND: Reference intervals are crucial decision-making tools aiding clinicians in differentiating between healthy and diseased populations. However, for children such values often are lacking or incomplete. METHODS: Blood samples were obtained from 692 healthy children, aged 6 months to 18 years, recruited in daycare centers and schools. Twelve common general clinical chemistry analytes were measured on the Abbott Architect ci8200 platform; sodium, potassium, chloride, calcium, albumin-adjusted calcium, phosphate, magnesium, creatinine (Jaffe and enzymatic), cystatin C, urea and uric acid. RESULTS: Age- and gender specific pediatric reference intervals were defined by calculating the 2.5th and 97.5th percentiles. CONCLUSIONS: The data generated is primarily applicable to a Caucasian population when using the Abbott Architect platform, but could be used by any laboratory if validated for the local patient population.
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