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  • Title: [Apoptosis modulation by PMA occurs independently of TsPO expression in squamous cell carcinoma cells].
    Author: Ruksha TG.
    Journal: Patol Fiziol Eksp Ter; 2012; (1):40-3. PubMed ID: 22629859.
    Abstract:
    Phorbol esters are known to modulate protein kinase C activity - enzyme involved in cell proliferation, differentiation and apoptosis regulation in skin cells. Besides it phorbol-12-myristate 13-acetate was shown possible to modulate promoter activity of TsPO - protein that is involved in steroidogenesis and cell proliferation regulation. Caspase-3 and TsPO expression was measured in squamous cell carcinoma cells after incubation with phorbol-12-myristate 13-acetate and ultraviolet radiation. Following alterations of TsPO and caspase-3 levels are explained by different mechanisms of regulation.
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