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  • Title: Neonatal cutaneous disseminated aspergillosis in a preterm extremely-low-birth-weight infant with favourable outcome at 3-year follow-up: a case report.
    Author: Manzoni P, Rizzollo S, Monetti C, Carbonara C, Priolo C, Mastretta E, Barberis L, Galletto P, Cigna P, Leonessa ML, Sala U, Gomirato G, Mostert M, Stronati M, Ruffinazzi G, Tzialla C, Jacqz-Aigrain E, Kaguelidou F, Farina D.
    Journal: Early Hum Dev; 2012 May; 88 Suppl 2():S65-8. PubMed ID: 22633518.
    Abstract:
    Invasive disseminated neonatal aspergillosis is an uncommon disease, with only scattered reports in literature in the last few years. Here we report on a 25-week gestational age, 730 g at birth preterm female infant who developed on day-of-life 10 multiple cutaneous exhulcerative lesions in her right arm, trunk and abdomen. Early recognition and diagnosis of these lesions as a due to cutaneous initial symptom of cutaneous disseminated aspergillosis, as well as prompt treatment with Liposomal amphotericin B + Itraconazole, secured successful recovery from the systemic infection. Skin lesions healed without any surgical treatment. The infant was discharged in good health. Long-term follow-up at three years of age revealed normality of all neurodevelopmental and cognitive parameters. To our knowledge, this is one of the very few cases of survival, free from sequelae, for a preterm infant affected by neonatal cutaneous disseminated aspergillosis.
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