These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Synthesis of friedelan triterpenoid analogs with DNA topoisomerase IIα inhibitory activity and their molecular docking studies.
    Author: Mandal A, Ghosh S, Bothra AK, Nanda AK, Ghosh P.
    Journal: Eur J Med Chem; 2012 Aug; 54():137-43. PubMed ID: 22633831.
    Abstract:
    Five highly oxygenated friedelan derivatives (3a, 3b, 4, 5a and 5b) were synthesized. The structures of these compounds were established on the basis of spectral (IR, 1D and 2D NMR, MS etc.) and chemical data. The molecules, including the parent compounds were screened for three-dimensional (3D) molecular docking on the crystal structure of topoisomerase IIα (1 bgw for topoisomerase IIα, PDB). Compounds 3a and 5a showed a dose dependent inhibition of catalytic activity of human topoisomerase IIα.
    [Abstract] [Full Text] [Related] [New Search]