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  • Title: [Diseases caused by diisocyanates. 2. Diisocyanate asthma].
    Author: Lubach D.
    Journal: Derm Beruf Umwelt; 1979; 27(1):5-10. PubMed ID: 226341.
    Abstract:
    Diisocyanates are widely used as polymerizing agents in the production of polyurethanes. Exposure to high concentrations of toluene diisocyanate (TDI) causes the development of toxic-irritative symptoms in the respiratory tract. It has been observed that some workers, after repeated exposures and a latent period of months to years, develop asthmatic symptoms upon re-exposure to minute concentrations of diisocyanates. An immunological mechanism for this typical extrinsic asthma has not been adequately documented.
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