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  • Title: Reference intervals for reproductive hormones in prepubertal children on the automated Roche cobas e 411 analyzer.
    Author: Zec I, Kučak I, Begčević I, Simundić AM, Tišlarić-Medenjak D, Megla ZB, Vrkić N.
    Journal: Clin Biochem; 2012 Oct; 45(15):1206-12. PubMed ID: 22634601.
    Abstract:
    OBJECTIVES: To establish reference intervals for luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), progesterone (P), total and free testosterone (T) and sex-hormone binding globulin (SHBG) in prepubertal children and to assess age- and gender-related differences. DESIGN AND METHODS: A total of 948 subjects, 480 girls and 468 boys, between 1 and 11 years of age, were included in this study. All assays were performed on a Roche cobas e 411 immunoassay analyzer. Reference intervals have been evaluated according to the most recent CLSI guidelines. RESULTS: Median values of LH, FSH and T were significantly higher in subgroups ranging from ≥ 8 to < 11 years, for both genders. In girls of that age, reference values of E2 were significantly higher than in younger ones, and in boys of the corresponding age. CONCLUSION: Established reference intervals are applicable to other laboratories that use the same instrumentation.
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