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  • Title: [Hypothyroidism prevalence and its relationship to high levels of thyroid peroxidase antibodies and urinary iodine in a population aged 35 and over from Armenia, 2009-2010].
    Author: Londoño ÁL, Gallego ML, Bayona A, Landázuri P.
    Journal: Rev Salud Publica (Bogota); 2011 Dec; 13(6):998-1009. PubMed ID: 22635001.
    Abstract:
    OBJECTIVES: Determining the prevalence of hypothyroidism and its interrelationship with peroxidase antibodies and high urinary iodine levels as a means for devising a set of recommendations for health authorities regarding the consumption of iodised salt and the early detection of thyroid disease. METHODS: 437 people in the municipality of Armenia (Quindío) participated in the study. ELISA tests were performed for free thyroxine, thyroid-stimulating hormone and thyroid peroxidase antibodies; a photocolorimetric analysis was carried out to determine urinary iodine levels. RESULTS: Hypothyroidism prevalence was 18.5%. Thyroid peroxidase antibodies were positive in 28.9% of the study population, with significantly higher prevalence amongst those with levels > 10 mIU/mL thyroid-stimulating hormone compared to 5.1 to 10 mIU/mL in those without it (OR 3.2) and smokers (O.R 3,4). Free thyroxine was normal in 98.2% of participants (> 5 mIU/mL thyroid-stimulating hormone levels) and 92% in those in whom > 10 mIU/mL thyroid-stimulating hormone levels were found. The average iodine level was 565.1; levels above 300 µg/L were obtained in 81.8% of the participants. CONCLUSIONS: Increased positive thyroid peroxidase antibody prevalence with increasing thyroid-stimulating hormone values could demonstrate a high risk of developing autoimmune hypothyroidism in Armenia; despite high iodine levels, a relationship with thyroid peroxidase antibodies or thyroid-stimulating hormone levels could not be established.
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