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  • Title: Antibodies to phosphatidylserine/prothrombin complex as an additional diagnostic marker of APS?
    Author: Žigon P, Čučnik S, Ambrožič A, Sodin Šemrl S, Kveder T, Božič B.
    Journal: Lupus; 2012 Jun; 21(7):790-2. PubMed ID: 22635235.
    Abstract:
    Antiprothrombin antibodies can be measured by ELISA using either a prothrombin/phosphatidylserine complex (aPS/PT) or prothrombin alone (aPT) as antigen. We aimed to compare the clinical features of autoimmune patients with avidity of aPS/PT and determine the diagnostic efficiency of aPS/PT and aPT for assessing antiphospholipid syndrome (APS). aPS/PT were of low (n = 9), heterogeneous (n = 31) and high (n = 8) avidity out of 48 cases. None of the samples with low avidity were positive in aPT ELISA. Among patients with heterogeneous or high avidity aPS/PT, there was a significantly greater number of patients with APS as compared to patients with low avidity (38/39 vs. 7/9; p < 0.05). No SLE patients had high avidity antiprothrombin antibodies.
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