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  • Title: Pharmacologic agents for mucus clearance in bronchiectasis.
    Author: Nair GB, Ilowite JS.
    Journal: Clin Chest Med; 2012 Jun; 33(2):363-70. PubMed ID: 22640851.
    Abstract:
    There are no approved pharmacologic agents to enhance mucus clearance in non-cystic fibrosis (CF) bronchiectasis. Evidence supports the use of hyperosmolar agents in CF, and studies with inhaled mannitol and hypertonic saline are ongoing in bronchiectasis. N-acetylcysteine may act more as an antioxidant than a mucolytic in other lung diseases. Dornase α is beneficial to patients with CF, but is not useful in patients with non-CF bronchiectasis. Mucokinetic agents such as β-agonists have the potential to improve mucociliary clearance in normals and many disease states, but have not been adequately studied in patients with bronchiectasis.
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