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  • Title: [Effects of dietary fat level on the xenobiotic metabolism enzymes activity and antioxidant enzymes in rats].
    Author: Kravchenko LV, Aksenov IV, Trusov NV, Guseva GV, Avren'eva LI.
    Journal: Vopr Pitan; 2012; 81(1):24-9. PubMed ID: 22642161.
    Abstract:
    Male Wistar rats received fat-free diet or diets containing 5, 10 and 30% of fat (sunflower oil + lard, 1:1) for 4 weeks. The direct relationship between dietary fat level and ethoxyresorufin O-dealkylase activity of CYP1A1, methoxyresorufin O-dealkylase activity of CYP1A2, pentoxyresorufin O-dealkylase activity of CYP2B1 and testosterone 6beta-hydroxylase activity of CYP3A was found. Activities of key enzymes of phase II xenobiotic metabolism (total activity of glutathione transferase, activity of UDP-glucuronosyle transferase) and antioxidant enzymes (catalase, glutathione peroxidase, glutathione reductase, paraoxonase-1 and heme oxygenase-1) also increased with higher dietary fat level.
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