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  • Title: Specific detection of integrin αvβ3 by light-up bioprobe with aggregation-induced emission characteristics.
    Author: Shi H, Liu J, Geng J, Tang BZ, Liu B.
    Journal: J Am Chem Soc; 2012 Jun 13; 134(23):9569-72. PubMed ID: 22642547.
    Abstract:
    Specific bioprobes with fluorescence turn-on response are highly desirable for high contrast biosensing and imaging. In this work, we developed a new generation bioprobe by integrating tetraphenylsilole, a fluorogenic unit with aggregation-induced emission (AIE) characteristic, with cyclic arginine-glycine-aspartic acid tripeptide (cRGD), a targeting ligand to integrin α(v)β(3) receptor. Emission of the AIE probe is switched on upon its specific binding to integrin α(v)β(3), which allows quantitative detection of integrin α(v)β(3) in solution and real-time imaging of the binding process between cRGD and integrin α(v)β(3) on cell membrane. The probe can be used for tracking integrin α(v)β(3) and for identifying integrin α(v)β(3)-positive cancer cells.
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