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  • Title: New topoisomerases inhibitors: synthesis of rutaecarpine derivatives and their inhibitory activity against topoisomerases.
    Author: Kim SI, Lee SH, Lee ES, Lee CS, Jahng Y.
    Journal: Arch Pharm Res; 2012 May; 35(5):785-9. PubMed ID: 22644846.
    Abstract:
    A series of rutaecarpine derivatives were prepared by employing previously reported methods and their inhibitory activities against topoisomerase I and II were evaluated. Among them, strongly cytotoxic 10-bromorutaecarpine and 3-chlororutaecarpine showed strong inhibitory activities against topo I and II.
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