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  • Title: Hyperinsulinaemia increases insulin action in vivo in white adipose tissue but not in muscles.
    Author: Takao F, Laury MC, Ktorza A, Picon L, Pénicaud L.
    Journal: Biochem J; 1990 Nov 15; 272(1):255-7. PubMed ID: 2264831.
    Abstract:
    The effect of 4 days of stable hyperglycaemia and resulting hyperinsulinaemia on insulin-induced glucose utilization by individual rat tissues was studied in vivo. The treatment produced a net increase in the glucose utilization index under both basal and insulin-stimulated (euglycaemic/hyperinsulinaemic clamp) conditions in white adipose tissue. On the contrary, glucose utilization was unchanged in aerobic muscles but was decreased in glycolytic skeletal muscles during the clamp.
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