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  • Title: Sesquiterpene lactones from Inula hupehensis inhibit nitric oxide production in RAW264.7 macrophages.
    Author: Qin JJ, Zhu JX, Zeng Q, Cheng XR, Zhang SD, Jin HZ, Zhang WD.
    Journal: Planta Med; 2012 Jun; 78(10):1002-9. PubMed ID: 22648378.
    Abstract:
    Phytochemical investigation of the aerial parts of Inula hupehensis Ling. led to the isolation and identification of 27 sesquiterpene lactones (1-27), including three new eudesmanolides (3-5), three new germacranolides (9-11), one new xanthanolide (16), two new carabrone derivatives (25-26), and 18 known sesquiterpene lactones. The structures were elucidated by extensive spectroscopic methods and comparison to previously reported spectroscopic data. All compounds were evaluated for their inhibitory effects against LPS-induced nitric oxide production in RAW264.7 macrophages, and compound 5 showed the strongest activity with the IC₅₀ value of 3.2 ± 0.4 µM.
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