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Title: Fluoride inhibition of polymorphonuclear leukocytes. Author: Gabler WL, Leong PA. Journal: J Dent Res; 1979 Sep; 58(9):1933-9. PubMed ID: 226570. Abstract: Significant inhibition of PMN metabolic activity by F- occurred at 0.1, 0.5 and 0.0 mM F- for O2- generation, 1-C14 CO2 release labeled glucose and NBT-reduction respectively. This inhibition resulted primarily from F- suppression of nonoxidative glucose metabolism. As the concentration of F- in the O2- generating system increased beyond 10 mM, a rise in production of O2- anion occurred, peaking at 20 mM F-, followed by a rapid decline.[Abstract] [Full Text] [Related] [New Search]