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  • Title: Association between ghrelin levels and BMD: a cross sectional trial.
    Author: Nouh O, Abd Elfattah MM, Hassouna AA.
    Journal: Gynecol Endocrinol; 2012 Jul; 28(7):570-2. PubMed ID: 22657566.
    Abstract:
    OBJECTIVE: Our aim was to determine whether the level of plasma total ghrelin varies with the menopause stage (pre-, peri-, and postmenopause). PARTICIPANTS AND INTERVENTIONS: Women were divided in three groups: premenopausal, perimenopausal and postmenopausal. All participants had bone mineral densitometry and blood assay of plasma ghrelin, estradiol E2. Correlation between plasma ghrelin levels, their reproductive status and BMD was done. RESULTS: The mean plasma level of ghrelin was significantly decreased in the perimenopausal and postmenopausal groups in comparison to the premenopausal group. A significant positive correlation was found between ghrelin and each of E₂ and BMD (at one or more of the three sites assessed) in all subjects, as well as, in peri- and postmenopausal women, whereas a significant negative correlation was found between ghrelin and FSH. CONCLUSION: It may be assumed that ghrelin can affect BMD. Whether ghrelin and estrogen work independent or through convergent mechanisms needs further studies.
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