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  • Title: Short term anti-tubercular drug therapy and hepatic microsomal enzyme activity. Antipyrine metabolism as an index.
    Author: Hamide A, Sivagnanam G, Raveendran R, Adithan C, Sivaraman V, Chandrasekar S.
    Journal: J Assoc Physicians India; 1990 Sep; 38(9):631-2. PubMed ID: 2266077.
    Abstract:
    The effect of short course chemotherapy on the drug metabolising capacity of the liver was studied in 7 newly diagnosed pulmonary tuberculosis patients, using antipyrine as a model drug. Antipyrine elimination half-life and plasma clearance rate were not significantly altered by 3 weeks of therapy. It is concluded that short course chemotherapy does not affect antipyrine metabolising enzyme activity.
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