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  • Title: Pyrrolidine based chiral organocatalyst for efficient asymmetric Michael addition of cyclic ketones to β-nitrostyrenes.
    Author: Singh KN, Singh P, Singh P, Lal N, Sharma SK.
    Journal: Bioorg Med Chem Lett; 2012 Jul 01; 22(13):4225-8. PubMed ID: 22672804.
    Abstract:
    An efficient asymmetric Michael addition of cyclic ketones to β-nitrostyrenes using secondary diamine as an organocatalyst derived from l-proline and (R)-α-methylbenzyl amine has been described. This pyrrolidine based catalyst 1 was found to be very effective to synthesize various γ-nitrocarbonyl compounds in good yield (up to 81%) with excellent stereoselectivity (up to >99:1 dr and >99% ee).
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