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Title: Total synthesis of neurymenolide A based on a gold-catalyzed synthesis of 4-hydroxy-2-pyrones. Author: Chaładaj W, Corbet M, Fürstner A. Journal: Angew Chem Int Ed Engl; 2012 Jul 09; 51(28):6929-33. PubMed ID: 22674881. Abstract: Treat me gently: for a selective synthesis of the unusually sensitive cyclophanic α-pyrone neurymenolide A, the chosen catalysts must be able to distinguish between six different sites of unsaturation, without scrambling any of the skipped π systems. This challenge was met with a new gold-catalyzed pyrone synthesis in combination with a molybdenum-catalyzed ring-closing alkyne metathesis.[Abstract] [Full Text] [Related] [New Search]