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  • Title: Synthesis of 3-substituted isocoumarins via a cascade intramolecular Ullmann-type coupling-rearrangement process.
    Author: Ge ZY, Fei XD, Tang T, Zhu YM, Shen JK.
    Journal: J Org Chem; 2012 Jul 06; 77(13):5736-43. PubMed ID: 22676390.
    Abstract:
    A simple and highly efficient strategy for the synthesis of 3-substituted isocoumarins through a copper(I)-catalyzed reaction of 1-(2-halophenyl)-1,3-diones has been developed. The procedure is based on a cascade copper-catalyzed intramolecular Ullmann-type C-arylation and rearrangement process. This methodology is tolerant of a wide range of substrates and applicable to library synthesis.
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