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  • Title: Xanthine oxidase inhibitory activity of constituents of Cinnamomum cassia twigs.
    Author: Ngoc TM, Khoi NM, Ha do T, Nhiem NX, Tai BH, Don DV, Luong HV, Son DC, Bae K.
    Journal: Bioorg Med Chem Lett; 2012 Jul 15; 22(14):4625-8. PubMed ID: 22677314.
    Abstract:
    A methanol extract of the twigs of Cinnamomum cassia was found to inhibit xanthine oxidase. Purification of the methanol extract afforded three new phenolic glycosides, cinnacasolide A-C (11-13), together with 10 known compounds (1-10). The structures of the three new compounds were determined by interpretation of spectroscopic data. Cinnamaldehyde derivatives 1-5 and 7 were significant inhibitors of xanthine oxidase, with IC(50) values ranging from 7.8 to 36.3 μg/mL. The results indicate that the acyl group of these cinnamaldehyde derivatives plays an important role in the inhibition of xanthine oxidase.
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