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  • Title: [Genome-wide association study with memory measures as a quantitative trait locus for schizophrenia].
    Author: Xiang B, Wu JY, Ma XH, Wang YC, Deng W, Chen ZF, Li ML, Wang Q, He ZL, Jiang LJ, Li T.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2012 Jun; 29(3):255-9. PubMed ID: 22678782.
    Abstract:
    OBJECTIVE: To assess the association between gene polymorphisms and memory function through a genome-wide association study (GWAS) of schizophrenia and control group. Memory cognition was used as a quantitative trait (QT). METHODS: Ninty-eight subjects with chronic schizophrenia and 60 matched controls were genotyped with HumanHap660 Bead Array. The results were correlated with quantitative traits including memory and memory delay. RESULTS: Five candidate genes, including RASGRF2 (rs401758, P = 8.03×10(-5)), PLCG2 (rs7185362, P= 4.54×10(-5)), LMO1 (rs484161, P=9.80×10(-7), CSMD1 (rs2469383, P= 2.77×10(-6)) and PRKG1 (rs7898516, P=6.94×10(-5)) were associated with memory cognition deficits. CONCLUSION: Using memory cognition as a quantitative trait, this Genome- wide association study has identified 5 susceptibility loci. With their association with nervous system development, neuronal growth, axon guidance and plasticity, brain development, above loci may play a role in the development of memory dysfunction in schizophrenia.
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