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Title: Biochemical characterization of Plasmodium falciparum hemozoin. Author: Goldie P, Roth EF, Oppenheim J, Vanderberg JP. Journal: Am J Trop Med Hyg; 1990 Dec; 43(6):584-96. PubMed ID: 2267961. Abstract: Hemozoin, the pigment granule which develops within the blood stage food vacuole of the malaria parasite Plasmodium falciparum, was biochemically characterized. Hemozoin was found to be composed of 65% protein, 16% ferriprotoporphyrin-IX (hematin), 6% carbohydrate, and trace amounts of lipid and nucleic acids. The overwhelming majority of the protein component is a mixture of native and denatured human globin non-covalently associated with the metalloporphyrin. Immunoelectron microscopy, employing anti-human hemoglobin as a probe, identified in situ association of hemoglobin with hemozoin. Hemozoin produced within diabetic blood had a higher proportion of carbohydrate, suggesting that the carbohydrate component comes from non-enzymatic glycosylation of hemoglobin.[Abstract] [Full Text] [Related] [New Search]