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  • Title: Excellent outcome of tubulointerstitial nephritis and uveitis: case report and five-year follow-up.
    Author: Zhou L, Li Y, Liu F, Peng Y, Liu Y, Li J.
    Journal: Ren Fail; 2012; 34(7):934-6. PubMed ID: 22681193.
    Abstract:
    Acute tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare disease usually having a good prognosis. But the recurrence of uveitis and the chronic progression of kidney injury are still main problems. We report a 15-year-old girl with TINU who showed proteinuria, pathological renal change, multiple organ dysfunction, and immune disorders. After 2 months of 1 mg/kg/day corticosteroid therapy, 24-h urine protein, liver function tests, and creatine kinase returned to normal level. In spite of this, steroid was tapered off slowly and small dose of steroid maintenance therapy lasted for 1 year. Her kidney and ocular symptoms did not recur during 5 years of follow-up. We suggest low-dose steroid maintenance therapy to decrease the recurrence of the TINU syndrome.
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