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  • Title: [Microdialysis study of release of adenine nucleotide breakdown products into the intercellular space of the myocardium in ischemia and reperfusion].
    Author: Kuz'min AI, Shul'zhenko VS, Selivanov VN, Saprygina TV, Medvedev OS, Kapel'ko VI.
    Journal: Biull Eksp Biol Med; 1990 Sep; 110(9):278-80. PubMed ID: 2268714.
    Abstract:
    Interstitial concentrations of adenine nucleotide breakdown products (ANBP)--adenosine (ADS), inosine (INS), hypoxanthine (HYP), in perfused rat hearts were measured during total ischemia and reperfusion by microdialysis technique. Progressive accumulation of ANBP in the interstitial space was observed during ischemia, but unlike INS and HYP, maximal ADS concentration was reached not by the end of ischemia but after the beginning of reperfusion. During reperfusion the qualitative accordance between changes in ANBP levels in the interstitial space and venous effluent was observed, but interstitial concentrations were several times greater.
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