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  • Title: [Usefulness of a slow-release tacrolimus for a patient with tacrolimus-induced renal injury after hemopoietic stem cell transplantation].
    Author: Hosonuma R, Fujiwara S, Sasazaki M, Hirata Y, Yamamoto C, Uesawa M, Oh I, Matsuyama T, Mori M, Ozawa K, Muroi K.
    Journal: Rinsho Ketsueki; 2012 Apr; 53(4):469-71. PubMed ID: 22687983.
    Abstract:
    In our facility, three patients developed tacrolimus (TAC)-induced renal dysfunction after allogeneic hemopoietic stem cell transplantation, although trough levels of TAC were within therapeutic ranges. They received an oral agent of slow-release TAC once a day instead of a regular form oral TAC twice a day. Following treatment with the prolonged-release agent, serum creatinine levels decreased and graft-versus-host disease (GVHD) did not occur. Use of this slow-release formulation may avoid toxic peak concentrations of TAC without the development of GVHD.
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