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  • Title: Synthesis of some novel thiocyanotopurine derivatives and investigation of their antimicrobial activity and DNA interactions.
    Author: Dilek Çelik G, Dişli A, Öner Y, Açık L.
    Journal: Chem Pharm Bull (Tokyo); 2012; 60(5):578-82. PubMed ID: 22689394.
    Abstract:
    A series of 6-thiocyanatopurine derivatives introduced with different alkyl groups in position 9 was synthesized. The structures of the synthesized compounds were evaluated via spectroscopic methods and elemental methods of analyses. All the synthesized compounds were screened for their antibacterial activities against Gram-positive and Gram-negative bacteria and for their antifungal activities against yeast strains. All the synthesized compounds showed better antibacterial activities against Gram-positive bacteria compared to Gram-negative bacteria. DNA interactions with pBR322 DNA were determined. Most of the compounds caused conformational changes in DNA.
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