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  • Title: Iron detoxifying activity of ferritin. Effects of H and L human apoferritins on lipid peroxidation in vitro.
    Author: Cozzi A, Santambrogio P, Levi S, Arosio P.
    Journal: FEBS Lett; 1990 Dec 17; 277(1-2):119-22. PubMed ID: 2269341.
    Abstract:
    Three recombinant human apoferritin variants were added to ferrous iron and the amount of lipid peroxidation produced by hydrogen peroxide was studied. The H-apoferritin had the strongest inhibitory effect on lipid peroxidation, probably due to its ferroxidase activity. The L-apoferritin inhibited lipid peroxidation slowly and only at neutral pH. The H-mutant 91, deleted of the last 22 C-terminal amino acids, and which is not able to form an iron core, had minimal effects on iron lipid peroxidation. It was concluded that both ferro-oxidase and iron mineralization activities are necessary for ferritin iron detoxifying action.
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