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  • Title: beta-Endorphin: synthesis of analogs modified at the carboxyl terminus with increased activites.
    Author: Li CH, Yamashiro D, Tseng LF, Chang WC, Ferrara P.
    Journal: Proc Natl Acad Sci U S A; 1979 Jul; 76(7):3276-8. PubMed ID: 226965.
    Abstract:
    Three analogs of human beta-endorphin (beta h-EP) have been synthesized: [Gly31]beta h-EP, [Gly31]beta h-endorphinamide, and [Gly31]beta h-endorphinylglycine. All are more active than beta h-EP in both the guinea pig ileum bioassay and the opiate receptor binding assay. The last two analogs are about twice as active as beta h-EP in an assay for analgesia. Modification at position 31 and extension at the COOH terminus may afford a route toward analogs with even greater biological activity.
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