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  • Title: Potent inhibition of norovirus 3CL protease by peptidyl α-ketoamides and α-ketoheterocycles.
    Author: Mandadapu SR, Weerawarna PM, Gunnam MR, Alliston KR, Lushington GH, Kim Y, Chang KO, Groutas WC.
    Journal: Bioorg Med Chem Lett; 2012 Jul 15; 22(14):4820-6. PubMed ID: 22698498.
    Abstract:
    A series of structurally-diverse α-ketoamides and α-ketoheterocycles was synthesized and subsequently investigated for inhibitory activity against norovirus 3CL protease in vitro, as well as anti-norovirus activity in a cell-based replicon system. The synthesized compounds were found to inhibit norovirus 3CL protease in vitro and to also exhibit potent anti-norovirus activity in a cell-based replicon system.
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