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  • Title: Use of four-dimensional analysis of power Doppler perfusion indices to demonstrate cardiac cycle pulsatility in fetoplacental flow.
    Author: Welsh A, Hou M, Meriki N, Stevenson G.
    Journal: Ultrasound Med Biol; 2012 Aug; 38(8):1345-51. PubMed ID: 22698501.
    Abstract:
    The aim of this study is to quantify fetoplacental cardiac cycle variation in virtual organ computer-aided analysis (VOCAL) power Doppler (PD) indices by novel application of spatio-temporal imaging correlation (STIC). We recruited 25 healthy women (20-34 weeks gestation) with uncomplicated, viable singleton pregnancies with anterior placentae. Three four-dimensional (4-D) STIC PD datasets of the fetoplacental circulation were obtained above the placental cord insertion. The vascularization index (VI), flow index (FI) and vascularization-flow index (VFI) were calculated offline using a standardized spherical sonobiopsy technique for all frames of the cardiac cycle. Clear maximum (systole) and minimum (diastole) values with progressive fluctuation were seen in the majority of datasets (VI 66/75 [88%]; FI 58/75 [77%]; VFI 68/75 [91%]). Variation from mean was: VI ± 3.33% (0.34%-9.69%); VFI ± 3.46% (0.27%-10.02%); FI ± 0.74% (0.14%-1.60%). All indices were significantly higher in systole than diastole (p < 0.001). Mean systolic:diastolic ratios were: VI 1.07 (SD 0.06), FI 1.01 (SD 0.01) and VFI 1.07 (SD 0.06). Intraclass correlation coefficients (ICCs) for the frames ascribed to systole and diastole and to the mean value across the cardiac cycle of the indices (95% confidence interval [CI]) were: systole VI 0.91 (0.83-0.96), FI 0.85 (0.72-0.92), VFI 0.92 (0.85-0.96); diastole VI 0.91 (0.84-0.96), FI 0.84 (0.71-0.92), VFI 0.92 (0.86-0.96); mean VI 0.91 (0.84-0.96), FI 0.84 (0.72-0.92), VFI 0.92 (0.86-0.96). There is clear cardiac cycle variation in VOCAL indices of fetoplacental blood flow, establishing the need to control for phase of the cardiac cycle, and raising the possibility of future 4-D evaluation of vascular flow change or impedance.
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