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  • Title: The influence of hydroquinone on tyrosinase kinetics.
    Author: Stratford MR, Ramsden CA, Riley PA.
    Journal: Bioorg Med Chem; 2012 Jul 15; 20(14):4364-70. PubMed ID: 22698780.
    Abstract:
    In vitro studies, using combined spectrophotometry and oximetry together with hplc/ms examination of the products of tyrosinase action demonstrate that hydroquinone is not a primary substrate for the enzyme but is vicariously oxidised by a redox exchange mechanism in the presence of either catechol, L-3,4-dihydroxyphenylalanine or 4-ethylphenol. Secondary addition products formed in the presence of hydroquinone are shown to stimulate, rather than inhibit, the kinetics of substrate oxidation.
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