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  • Title: Thermoresponsive micropatterned substrates for single cell studies.
    Author: Mandal K, Balland M, Bureau L.
    Journal: PLoS One; 2012; 7(5):e37548. PubMed ID: 22701519.
    Abstract:
    We describe the design of micropatterned surfaces for single cell studies, based on thermoresponsive polymer brushes. We show that brushes made of poly(N-isopropylacrylamide) grafted at high surface density display excellent protein and cell anti-adhesive properties. Such brushes are readily patterned at the micron scale via deep UV photolithography. A proper choice of the adhesive pattern shapes, combined with the temperature-dependent swelling properties of PNIPAM, allow us to use the polymer brush as a microactuator which induces cell detachment when the temperature is reduced below [Formula: see text]C.
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