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  • Title: Nucleotide sequence of the rep gene of staphylococcal plasmid pCW7.
    Author: Balson DF, Shaw WV.
    Journal: Plasmid; 1990 Jul; 24(1):74-80. PubMed ID: 2270231.
    Abstract:
    Previous heteroduplex mapping studies showed that staphylococcal plasmid pCW7 belongs to the pT181 family of small antibiotic resistance plasmids which replicate by a rolling-circle mechanism. Replication in each case is initiated at the plasmid origin (ori) by a plasmid-encoded protein. Rep, which makes a sequence-specific single-stranded nick to form a covalent Rep-ori replication intermediate. A comparison of sequencing results for the repN gene of pCW7 with data for the products of five other homologous rep genes allows a prediction to be made of the segments of the primary structure of Rep which are likely to be responsible for plasmid-specific recognition of the ori region by each Rep protein.
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