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  • Title: [Results of the treatment of neurosyphilis with high doses of crystalline and procaine penicillins].
    Author: Starzycki Z, Markiewicz J, Mayer J, Bogdaszewska-Czabanowska J.
    Journal: Przegl Dermatol; 1990; 77(5):359-62. PubMed ID: 2270298.
    Abstract:
    The results of the treatment in two groups of patients with neurosyphilis are compared. In 23 cases, i.v. infusions of crystalline penicillin were given for 10 days in daily dose of 20-24 mega U., combined with probenecid. Then it was followed by i.m. procaine penicillin in daily dose of 1.2 mega U., in total dose 12-50 mega U. The mean duration of follow-up was 7,8 months. The second group (34 cases) was treated with procaine penicillin i.m. in daily dose of 1.2 mega U., the total dose was 24-60 mega U. The mean duration of follow-up was 2.5 years. The differences between the results of the treatment in both groups were not significant. In 3 reinfected patients with early asymptomatic neurosyphilis in spite of intensive treatment with penicillin sero- and cerebro-spinal fluid-resistant syphilis developed.
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