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  • Title: Immunotherapies in rheumatologic disorders.
    Author: Miller AV, Ranatunga SK.
    Journal: Med Clin North Am; 2012 May; 96(3):475-96, ix-x. PubMed ID: 22703852.
    Abstract:
    Over the past several decades, rheumatology has directed its focus to understanding and countering the immune dysregulation underlying autoimmune diseases with rheumatologic manifestations. Older therapies, effective though poorly understood, are being scrutinized anew and are yielding the immune-modulating mechanisms behind their efficacy. New therapies, the "biologics," are drugs tailored to address specific immune defects and imbalances. This article discusses the current standard and biologic immunotherapies of the rheumatic diseases, correlating our current understanding of their mechanisms with dysfunctions believed to be present in the major autoimmune syndromes, especially rheumatoid arthritis and systemic lupus erythematosus.
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