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  • Title: Angelicae Gigantis Radix regulates mast cell-mediated allergic inflammation in vivo and in vitro.
    Author: Sohn Y, Lee HS, Park HJ, Lee H, Lee H, Choi H, Jeong CH, Bu Y, Jung HS.
    Journal: Food Chem Toxicol; 2012 Sep; 50(9):2987-95. PubMed ID: 22705330.
    Abstract:
    Angelicae Gigantis (AG) Radix, commonly used medicinal food, has been reported as a promising candidate for inflammatory diseases. However, the anti-allergic effects of AG and its molecular mechanisms have yet to be clarified. The present study investigated the anti-allergy effects of ethanol extracts of AG on mast cell-mediated allergic inflammation in vivo and in vitro. The finding of this study demonstrated that AG reduced anti-dinitrophenyl IgE antibody-induced passive cutaneous anaphylaxis, compound 48/80-induced histamine release, 2,4-dinitrofluoro benzene-induced contact hypersensitivity. In addition, AG inhibited the production of interleukin (IL)-6, IL-8, and TNF-α, as well as the activation of Jun N-terminal kinase and nuclear factor-κB in phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated human mast cells. In conclusion, our results provide a novel insight into the pharmacological actions of AG as a potential candidate for use in allergic inflammatory diseases.
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