These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Association of IL23R polymorphisms with psoriasis and psoriatic arthritis: a meta-analysis.
    Author: Zhu KJ, Zhu CY, Shi G, Fan YM.
    Journal: Inflamm Res; 2012 Oct; 61(10):1149-54. PubMed ID: 22706445.
    Abstract:
    BACKGROUND: The association of variants in the IL23R gene with psoriasis and psoriatic arthritis (PsA) is a robust genetic finding OBJECTIVES: To assess whether combined evidence shows the association between IL23R polymorphisms and susceptibility to psoriasis/PsA. METHODS: We conducted a meta-analysis to examine the association between the IL23R rs11209026 (Q381R), rs7530511 (L310P), and rs2201841 polymorphisms and psoriasis/PsA. RESULTS: Thirteen articles met the inclusion criteria and contributed data to the meta-analysis. For rs11209026, the odds ratios (ORs) of minor alleles for psoriasis and PsA were 0.616 [95 % confidence interval (CI) 0.563-0.674] and 0.630 (95 % CI 0.524-0.757), respectively. For rs7530511, the pooled ORs were 0.820 (95 % CI 0.764-0.879) for psoriasis and 0.875 (95 % CI 0.766-1.000) for PsA; for rs2201841 the OR was 1.121 (95 % CI 1.031-1.219) for psoriasis. In genotypic analysis, the association of rs11209026 (A) and rs7530511 (T) were compatible with the dominant model (P < 0.0001, P = 0.001 respectively). The overall ORs for GG vs. AA (OR 1.339; 95 % CI 1.151-1.558), GG vs. GA (OR 1.143; 95 % CI 1.004-1.300), dominant (OR 1.226; 95 % CI 1.143-1.316), and recessive (OR 1.254; 95 % CI 1.115-1.411) models of rs2201841 were all significantly increased in psoriasis. No publication bias was present. CONCLUSIONS: Our results demonstrate a significant association between IL23R gene polymorphisms and psoriasis/PsA.
    [Abstract] [Full Text] [Related] [New Search]