These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Effect of the histone deacetylase inhibitor sodium butyrate on the viability and life span in Drosophila melanogaster].
    Author: Vaĭserman AM, Koliada AK, Koshel' NM, Simonenko AV, Pasiukova EG.
    Journal: Adv Gerontol; 2012; 25(1):126-31. PubMed ID: 22708457.
    Abstract:
    Histone acetylation (one of the most important epigenetic mechanisms controlling gene expression) has been recently shown to be involved in life span (LS) determination. There are some data indicating the geroprotective potential of histone deacetylase (HDAC) inhibitors. In the present study, the effects of HDAC inhibitor, sodium butyrate (SB), on the parameters of viability and LS of Drosophila melanogaster were studied. Since SB is an efficient inducer of epigenetic changes, it can be assumed that its use as a life-extending agent (geroprotector) can be quite promising.
    [Abstract] [Full Text] [Related] [New Search]