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  • Title: Evaluation of temporary portal vein arterialization: the minimum arterialized blood flow for maintaining liver viability.
    Author: Yamaguchi M, Higashiyama H, Kumada K, Okamoto R, Ueda J, Shimahara Y, Ozawa K.
    Journal: Transpl Int; 1990 Oct; 3(3):162-6. PubMed ID: 2271087.
    Abstract:
    The effect of temporary portal vein arterialization (PVA) on hepatic energy metabolism was investigated by changes in the arterial blood ketone body ratio (KBR) and hepatic energy charge (EC) level in 17 dogs. The KBR decreased markedly after clamping the hepatic hilar vessels combining mesocaval shunt and remained at a low level throughout hepatic ischemia. After PVA, the KBR was rapidly restored and maintained at sufficient levels. EC at 60 min after arterialization also recovered to the preclamping level. By reducing the arterial shunt flow, the critical point of arterialized blood flow for maintaining the KBR at high levels was assessed to be about 10% of the total hepatic blood flow (THBF). These findings demonstrate that temporary PVA is an effective method for maintaining the functional capacity of the liver, and that the minimum arterialized blood flow needed to preserve liver viability is only about 10% of the total hepatic blood flow.
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