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  • Title: Analgesic activity of various extracts of Holoptelea integrifolia (Roxb.) Planch leaves.
    Author: Rizwani GH, Mahmud S, Shareef H, Perveen R, Ahmed M.
    Journal: Pak J Pharm Sci; 2012 Jul; 25(3):629-32. PubMed ID: 22713952.
    Abstract:
    The various extracts of leaves Holoptelea integrifolia (Ulmaceae) were investigated for analgesic activity in mice by tail flick method. The fresh plant leaves of H. integrifolia were collected, dried, cleaned, weighed and chopped into small pieces and percolated in ethanol. The fractionation of crude extract, followed by the addition of distilled water, ethyl acetate and n-butanol to an aqueous portion of each solvent, to obtain the dried masses of each four layers. Qualitative chemical examination indicates the presence of secondary metabolites such as alkaloids, flavones, phenol, steroids, tannins and triterpenoids. No acute oral toxicity was observed and extracts considered being safe at the dose of 50-2000 mg/kg body weight. At the dose of 500 mg/kg various extracts of leaves of H. integrifolia were found statistically significant (P<0.05). A maximum effect was established at 150 min, after drug administration. Diclofenace sodium used as a standard.
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